When a series of murders take place amidst the shooting of a movie,the CBI begin to suspect eccentric film director Rana to be a serial killer.

After the passing away of his dark-skinned wife, from who they sired Uday, Dubai-based criminal don, Shankar Shetty re-married a fair-skinned woman, who gave birth to fair-skinned Sanjana. After the couple’s passing, Uday takes over in his dad’s footsteps, and takes it upon himself to try and get Sanjana married – in vain, as no one wants to be associated with a crime family. Then Uday’s associate, Sagar Pandey, aspiring live-action painter, who had loved Iravati, got beat-up by her brothers, and was re-named Majnu, assists in finding a young man, Rajiv, who lives with his maternal uncle, Dr. Ghunghroo and aunt, and through extortion compels Ghunghroo to accept this alliance. But Ghunghroo, at the very first opportunity, gets Rajiv to fall in love with another young woman in Sun City, South Africa. When the time comes to get Rajiv formally engaged to this woman, he finds out that Sanjana and she are the very same woman.

In Mumbai, the people who had migrated from Tamil Nadu are living in the slum of Dharavi. Union Minister Haridev “Hari Dhadha” Abhayankar (Nana Patekar) tries to evict the people and seize their land. Over the years, he becomes a minister and plans to clear the area to construct buildings with the help of his supporter Vishnu Bhai (Sampath Raj). Karikaalan (Rajinikanth), living in Dharavi, opposes it to protect the area and his people. His ex-lover Zareena (Huma Qureshi) returns to Dharavi as a representative non-governmental organization that hopes to improve Dharavi’s living standards. Hari Dhadha’s assassination attempt on Kaala kills Kaala’s wife Selvi (Easwari Rao) and elder son Selvam (Dileepan). Kaala decides to take revenge on him and encourages the people to protest against the government. Hari Dhadha creates a curfew in Dharavi with the help of his supporter Inspector Pankaj Patil (Pankaj Tripathi). Kaala fights with Hari Dhadha’s henchmen and the police. Kaala’s younger son Lenin (Manikandan), daughter-in-law Charumathi “Puyal” (Anjali Patil), and brother-in-law Vaaliyappan (Samuthirakani) fight alongside him. Pankaj gets arrested after a video taken by a reporter Praveen (Ramesh Thilak) provides evidence that the henchmen were brought into Dharavi to create problems with the police’s support. The police believes Kaala is dead and informs the media, but the people of Dharavi deny the news of his death. Hari Dhadha enters Dharavi at a function for constructing a new building. Here, Kaala reappears amongst the crowd. Hari Dhadha is killed by the people of Dharavi in a stampede, and the government stops the scheme. With Dharavi’s success, many slums start to follow Kaala’s way of protest to protect their neighbourhood, irrespective of illegal land occupation.