Satya and Deepthi are lovers living in Visakhapatnam. A dreaded don, Veeru Bhai, lusts for Deepthi. When Deepthi’s parents are killed, she and Satya escape. They board a bus on route to Hyderabad, but the bus is stopped unexpectedly and boarded by three men: Veeru’s henchman Deva, Veeru’s brother Ajay, and a corrupt police inspector, Shravan. They kill Deepthi in front of Satya, and he suffers an almost-fatal stab wound. Before the three leave, they set fire to the bus, leaving Satya to his death after stabbing him. However, Dr. Shailaja saves Satya by giving him a new face and skin. Ten months later, Satya wakes up from his coma.

The film starts in the 1980s. A young Shiva (Jiiva) is trained in the ancient Indian martial art Kalarippayattu by his grandfather (Prakash Raj) to be bold and brave and fight against all odds, especially all that’s evil. Shiva grows up with his grandfather’s words as his Bhagavad Gita. However, Shiva’s parents (Udaya Murthy (Jayaprakash) and Lakshmi (Lakshmi Ramakrishnan) want him to lead a peaceful life. Shiva gets arrested by the police after fighting with a law student Guna, who is in Gowri’s (Sentrayan) gang. Enters Priya (Shriya Saran), also a law student. She is the daughter of a police official (Babu Antony). She bails Shiva out and falls for him after seeing him fight for other people’s good. Eventually, Shiva too falls for her.

Veera, a forest brigand was killed by police officers. A police officer who is suspected to have become this brigand’s man has gone underground and a team of cops (Richard, Bharani and co) are sent to the forest to capture/kill him. They meet Akhila (Arundhati), a woman who claims to live in the forest, who, they think is a prostitute. Meanwhile, in a parallel track, there is a young woman Dhamini (Manochitra), who agrees to be driven to the same forest by Sivaji (Vimal), a debauched car driver.

Once a young man named Tamil learns that a businessman is planning to build a factory in his village, he tries to stop the plan for fear of pollution.

A handicapped man Krishna (Suriya) arrives at Mumbai from Kanyakumari at a train station after boarding a train from there. He, along with a taxi driver Raja (Soori), travel around Mumbai to look for his elder brother, Raju. Raja tries to get to know about Krishna but is unable to get any details about him from him. Krishna rents a hotel room, takes a shower, and changes his clothes. He gets Raja to take him to a club, where Krishna then tries to meet an old associate of Raju named Amar, who is a very powerful gangster through his henchmen, but fails. He then meets a close friend of Raju named Rajiv (Asif Basra), who overheard his conversation with Amar’s henchmen. Rajiv tells Krishna that Raju is Raju Bhai (Suriya), a powerful and feared gangster. He then tells things to Krishna about Raju, until he passes out from being drunk.

Thenmozhi (Anushka Shetty) arrives in Boston to meet her niece. While leaving for Chennai, in the airport, she gets a free upgrade and sits next to Sathyadev (Ajith Kumar). During the flight, she starts vomiting due to overeating and with Sathyadev’s help she feels better, so she develops a crush on him. The next day in Chennai, Sathyadev and Thenmozhi are at a cafe, when a criminal named Victor (Arun Vijay) comes to abduct Thenmozhi, but fails due to Sathyadev subduing him.

The film goes back to Chennai 1989 (then known as Madras) where Sathyadev’s father (Nassar) is killed by a criminal. From there, Sathyadev makes a decision and a few years later is seen in a jail with Victor. They escape from jail, get Victor married to Elizabeth alias Lisa (Parvathy Nair), and meet a criminal Matthew (Stunt Silva). Sathyadev infiltrates the gang as an IPS officer, kills Matthew, and injures Victor. In an attempt to stop a gangster, he meets Hemanika (Trisha Krishnan), who needs to get to a hospital due to her being pregnant. Two years later, he meets Hemanika and her child Isha (Baby Anikha). After seeing each other for four years, they decide to get married. On the day of their marriage, Hemanika is killed: Sathyadev and Isha are heartbroken. Sathyadev decides to quit and travels with Isha around India along with his colleague Richard’s (Vivek) help. After he returns, his neighbour’s children have gone missing. He discovers that Victor is helping his boss Muruganandham (Suman), stealing organs illegally with foreign doctors to help him. Sathyadev is able to find the children and their next target, Thenmozhi.

Karnan, a fearless village youth, must fight for the rights of the conservative people of his village, due to the torture given by a police officer.

A spoiled young heiress marries a poor man in order to inherit her grandfather’s property.

Marudhamalai, a cop, gets involved in a scuffle with the local gangster and helps the villagers get rid of his atrocities.

The story is about a group of friends who wish to go to college together regularly. The group consists of Naresh, Sai Ram Shankar, Abhishek, Swathi and Sherin. Once, one of their friends named Lakshmi gets engaged. So the team decides to have a nice party before she gets married.

The son of an egoistic businessman falls in love with an egoistic girl and has to convince her egoistic mother in order to marry her.

A street racer and a traffic cop end up becoming brothers-in-law. Can they accept each other given their previous hostile history?