The story takes place in Panimalai, a hill city, during a spring season. The film begins with RJ Balaji coming to Panimalai to be a guest of a live radio show. In the middle of the show, he starts coughing severely and suddenly loses his voice. He is diagnosed with a new type of virus called the mute flu that causes sudden muteness and sometimes even death.
Aravindh (Dulquer Salman) is a sales representative working with a glue company. His dream is to become a radio jockey, and he even attends interviews with a FM station. As the mute flu spreads across the city, the state government sends Health Minister Sundaralingam (Pandiarajan) to Panimalai to take care of the situation. The people are asked to undergo a medical checkup to check whether they are affected by the virus or not. Aravindh goes to the hospital and meets Anjana (Nazriya Nazim), a junior doctor, who believes that talking is the only cause of all the problems in the world and if people keep things to themselves things will be very fine. Anjana is in a relationship with Vinodh (Abhinav), a possessive guy who always commands her on what she should do and what she should wear. Anjana lives with her father and stepmother Vidhya (Madhoo). Since Anjana lost her mother at a young age, she is reluctant to accept Vidhya as her mother, though she is a sweet and caring woman, and always maintains a distance from her. Vidhya is an aspiring writer who is trying to get her husband’s (Abhishek Shankar) attention and support to write her third book. Her husband finds no time to talk to her as he is too busy with his work.

Harish is a good-for-nothing happy-go-lucky-guy who idles away his time in his village. He is a consummate liar and always tries to boast of himself through lies. With lies he tries to impress his friends and villagers boasting of his romantic escapades. And one such lie involving a village belle (played by Malavika Menon) lands him in troubles. How he extricates himself from these troubles forms the rest of the story.

A young actor’s stormy childhood and early adult years as he struggles to reconcile with his father and deal with his mental health.

Rohan Bhatnagar (Hrithik Roshan) is a kind, happy young man who has been blind since birth and works as a voice-over artist for a living. Through friends, he meets Supriya Sharma (Yami Gautam), a working woman who is also blind, but proudly independent. The two fall in love and get married.
One night, on their way back home after dining out, they are interrupted by Amit Shellar (Rohit Roy), a local goon and younger brother of Madhavrao Shellar (Ronit Roy), a well-known politician. He and his friend Wasim, drunkenly misbehave with the couple, enraging Rohan, and they have a heated exchange.

Trying to hold the lead in the Space Race, the Soviet Union is preparing two cosmonauts for the first spacewalk.

A vegetable vendor marries a girl against her father’s wish. The couple, with the help of their respective mothers, manage to hide it from the girl’s father till she gives birth to a child.

A fictitious story about two legendary revolutionaries and their journey away from home before they started fighting for their country in 1920’s.

Mosakutty an orphan and uneducated involves himself in highway robbery along with his close aide Sendru. A local bigwig Virumandi misuses Mosakutty right from his young age for his personal gains and takes away the booty and pay the latter only pittance. Meanwhile, a certain unexpected incident leads Kayal, the only daughter of Virumandi who is a student of a local college fall for Mosakutty. However, as expected this didn’t go well with Virumandi who tries to kill Mosakutty through his henchmen. But he survives and when he returns to the village, he could not find Kayal at her place. The rest is whether Mosakutty succeeds in his search for his lover or not.

Ennul Aayiram is about the journey of a 25-year old and the various problems he encounters.

The story of Karthikeyanum Kanamal Pona Kadhaliyum is about a youngster (Deepak) whose lover deserts him and goes away. He befriends another girl (a traffic constable). The rest of the movie is the aftermath of their friendship and other incidents.

From a small rural village, Eashwaran (Srikanth) heads to the bigger city of Chennai with his father (Murali), seeking medicine to treat an illness. While in town, they live at the home of Eashwaran’s brother (Shyam Ganesh), who is caught up in a dangerous web of corruption involving a thug Aditya (FEFSI Vijayan). As Aditya continues to head dirty deals with local officials, Eashwaran is in over his head and may need his brother’s help.

The film begins with a narration on how India has been turned into a landfill site for domestic and foreign countries, with the countries dumping even ammunition waste onto Indian soil. In Delhi, Balusamy, aka Balu (Arya), a communist leader, is convicted by the court on counts of robbery, murder and treason is given death sentence. Despite Balu’s request to execute him as a martyr by shooting, the court orders that he be hanged within a month’s time by a professional executioner or hangman. He is escorted to a high security prison complex in Chennai by Macaulay (Shaam), an honest, law abiding police officer who is given the charge of monitoring him until his execution. The prison provides freedom to all prisoners, including Balu, to do whatever they want, as long as they do not cause unrest. Balu is instantly admired by the inmates for his patriotism and philosophy as well as his empathy with the inmates. They view him as a spokesperson to the prison officials on behalf of them.