The story revolves around a remote village in Andhra Pradesh plagued by a strange disease killing a lot of people. The soothsayer of the village predicts that God would come to their village for rescue. Meanwhile, Raju (Mahesh Babu) a cab driver in Hyderabad goes to Rajasthan to handover an insurance cheque to a man’s family who dies in his car. In a strange situation, Raju meets a man from the village and gets to know about their problem. Soon Raju realizes he is none other than the God-sent, the soothsayer predicted, and the rest of the story is all about how Raju takes up the responsibility to rescue the village from the clutches of evil.

Murali moves into a house for rent, which is owned by Sumathi’s father. Murali falls in love with Sumathi and befriends Selvi, who is the house-maid’s daughter whose help he seeks to win over Sumathi.

An honest police officer gets in to a conflict with Rana. Their enmity worsens when Tamilarasan refuses to obey Rana’s order in a critical situation.

Vandiyathevan sets out to cross the Chola land to deliver a message from the Crown Prince Aditha Karikalan. Kundavai attempts to establish political peace as vassals and petty chieftains plot against the throne. Unrest grips the land as a long-tailed comet arrives, signalling a time of turmoil.

Hanumantha Rao and Vishwanath are old college buddies. Their young children, Prabha and Nandini respectively, are also friends. But in the 1980’s they are separated as Vishwanath moves with his family from India to Switzerland. Years pass and Prabha is now a grown man and a leader of music group. When he rejects the advances of gangster’s daughter, he finds himself in hot water. The gangster tries to force Prabha into marriage, and the only way to save himself is to convince the sentimental don that his heart is already taken.

A hot-blooded student union leader falls for a state-level cricketer but his anger management issues and violent streak threatens to derail their love story.

Bhoominathan is an astronaut at NASA who has to resolve an unfinished business in his village before taking off to Mars.

A young man Ajay (cancer victim) meets two lovely women Renu (wife) and Vidya (journalist) in his life.

A music shop owner falls in love with a girl from a circus troupe that has come to his village. But caste and class stand in the way.

Desperate measures are taken by a man who tries to save his family from the dark side of the law, after they commit an unexpected crime.

An unhappily married aristocrat begins a torrid affair with the gamekeeper on her husband’s country estate.

Parasuraman (Vijayakumar) is a rich businessman who lives with his wife Pattammal (Srividya), elder son Raghu (Raghuvaran), younger son Sriram (Rajiv Krishna), and a physically-challenged daughter. Raghu is more matured, and he assists his father in managing the business, while Sriram is a fun-loving person. Parasuraman hates Sriram’s careless attitude, and he keeps scolding him often for his irresponsible behavior. Rajeshwari (Bhanupriya) is the Raghu’s wife, and she is close to her family members.