Perazhagi ISO revolves around a 60-year-old granny who turns into a 20 years young beautiful girl after she accidentally falls into the hands of a business organization researching on the process of age reversing.

Murugesan (Livingston) is a rich landlord in a village but is illiterate as well as innocent. He is in love with his cousin Maheshwari (Devayani) right from childhood. Maheshwari also likes Murugesan but she wants him to overcome his innocence and be brave. Santhamoorthy (Ponnambalam) is Murugesan’s half brother and enmity prevails between him and Murugesan. Chinthamani (Vindhya) is a dancer who comes to Murugesan’s village to perform. Chinthamani’s mother forces her into prostitution but Murugesan saves her and accommodates in his farm house.
Murugesan and Maheshwari’s wedding is fixed and the day before wedding, Santhamoorthy tries to kill Murugesan but Murugesan fights back the goons. Murugesan who is drunk now rushes to his farmhouse to get some weapons to kill Santhamoorthy. Chinthamani who lives in the farm house tries to stop Murugesan from committing the murder and accidentally they enter into a physical relationship. Murugesan feels guilty of the incident and wants to cancel his wedding with Maheshwari. But Maheshwari’s father (R. Sundarajan) convinces Murugesan to not cancel the wedding.

Ganesh is a slum boy who drives an auto to support his family. Bhuvana is the neglected daughter of a rich man and is in search of true love. Bhuvana is drawn to Ganesh’s honesty and good heart. She confesses her love to Ganesh, but he turns her away, saying that a rich girl like her would never be able to live a life of poverty with him. Bhuvana tells Ganesh that she will show him she can do it and comes to his house with just the clothes on herself. As Bhuvana and Ganesh share a happy love and understanding, life is all roses, until a storm disrupts their happiness. Bhuvana meets with an accident and fights for her life. The doctors say nothing but a heart transplant could save her. Ganesh has no money for the operation and is unable to bear the thought of a life without Bhuvana.

The story is of an aspiring shuttler, who gives up his passion and takes a job in Singapore so that his parents can be proud of him. But what destiny has in stock for him is Kan Pesum.

Thamizh (Prashanth) leads a happy life with his mother (Manorama) and sister-in-law Kalaichelvi (Urvasi). Thamizh’s brother (Livingston) is working in Kuwait, and he too dreams of joining him there. Their tenant Meenakshi (Simran) and Thamizh fall in love. When the goons of Periyavar (Ashish Vidyarthi) injure Thamizh’s niece, he stops Periyavar’s car on the road and questions him. He then beats up one of Periyavar’s goons when insulted. This makes him Periyavar’s target, and though he tries to withdraw from the violence, he is forced to join forces with Rathnam (Nassar), Periyavar’s sworn enemy, and eventually defeats him.

Surya (Ramesh), an introvert by nature loves his classmate Priya (Pooja) from childhood but has never expressed his feelings towards her. Meanwhile, Surya’s another classmate Ajay also tries to woo Priya in which he succeeds to an extent. Priya does not like Surya as she views him as a nerd. One day, Surya gets frustrated as he is not being liked by anyone and cries loudly in a beach where he finds a small idol of a God. He holds the idol saying that it is better to be invisible in this world rather than being disliked by everyone.

The story focuses on the life of Sabhapathy (Nakul). He is the football-crazy son of an alcoholic and lives in the slums. However, he lives a comfortable life and plays football with his mates as he completes his college career. He meets Meera (Sunaina) and develops a liking for her. He slowly starts to love her but is afraid to express his love since she is rich and would react hastily. However, he later does confirm his love to her, and she accepts. When Sabha leaves for a football match with his college, he promises he will propose to her as soon as he gets back. Sabha returns from his match to only find out that Meera has died. He slips into a psychotic depression, travelling with Meera’s dead body. To make matters even worse, the police are after him. The film ends as he commits suicide after killing Meera’s uncle Kasirajan (Hariraj), who murdered her in order to gain her wealth.

When Ramakrishnan is caught with a prostitute, he introduces her to his wife as Thiru’s girlfriend. Thiru, feeling helpless, goes along with the plan at the cost of upsetting his own girlfriend, Susi.

Ashok (Raghava Lawrence) is a good-for-nothing youth whose only aim is to enjoy life by drinking and dancing the night away with his friends. To this end, he even swindles his father (Pyramid Natarajan) regularly off of his hard earned money. He meets Priya (Anu Prabhakar) and soon her beauty and outlook on life make him fall for her. When he proposes to her, threatening to kill himself if she doesn’t accept his love, she promises that she would accept him if he makes a name for himself. Spurred by her words, Ashok starts working hard. But what he doesn’t know is that Priya is already in love with Arvind (Kunal) and that her promise to him was just to prevent him from taking the extreme step on her rejection.

When Jana murders Madhavan, Ram decides to take the blame. Later, Jana’s body is found on the railway tracks, and Ram and Anita, a journalist, investigate his death.

Mahesh (Mirchi Senthil) is an unemployed man living in Thiruvarur who enjoys hanging out with his friends. His father (Livingston) is unhappy with his son’s irresponsible lifestyle and attempts suicide. Mahesh then begins to search for a job, and with the help of his friend, Appu Kutty (Muruga Dass), finds a job in Singapore. He meets Janani (Iniya), who is a Singapore citizen, and attempts to marry her in order to obtain citizenship. but the truth was that she was not a Singapore citizen.

The story revolves around an insecure teetotaler Sarathy Raman (Karunas), who feels bad due to his dark skin (his wife Vasanthi (Karthika) is fairer than him), who is often the brunt of many jokes. Because he feels inferior to his wife, he begins to suspect her of infidelity and thinks that she will one day elope with a lover. After a misunderstanding, Sarathy and his mother are estranged, which further weakens the bond between Sarathy and Vasanthi. How Sarathy resolves his issues and gets back together with Vasanthi forms the rest of the story.

The security guard of a mall, who belongs to the Gurkha community, becomes the saviour of several people who have been kept under siege by some terrorists.

Like a gardener with all his tenderness for his flowers, an old vigilante takes under his wing a young couple of runaway lovers. He lavishes on them love and safety. The father of the young woman who tries to eliminate the lover, is none other than the sworn enemy of the upholder of the law. It is because of him, that the woman of the hero lost their unique heir and cannot give birth any more from now on… Horrible memories surface and put the old upholder of the law on a war footing, for his ultimate confrontation…