Surya (Ramesh), an introvert by nature loves his classmate Priya (Pooja) from childhood but has never expressed his feelings towards her. Meanwhile, Surya’s another classmate Ajay also tries to woo Priya in which he succeeds to an extent. Priya does not like Surya as she views him as a nerd. One day, Surya gets frustrated as he is not being liked by anyone and cries loudly in a beach where he finds a small idol of a God. He holds the idol saying that it is better to be invisible in this world rather than being disliked by everyone.

Madhu (Githan Ramesh) always roams on a bike. Mercy (Priyamani) and Esther (Jahnavi) are friends and hostel mates. Mercy believes in Jesus and is very kind and humble towards others. Esther is bold, glamorous in dressing, and teases everyone. One day, when Esther teases Madhu, he kisses her publicly. Madhu falls in love with Mercy at first sight when she rescued a puppy from raining. Madhu often gets the chance to meet Mercy. He comes to the hostel and expresses his love to Mercy, but she denies his love. After examination, Mercy goes to her hometown Mahi. Madhu follows her. Her father Siluvai (Ashish Vidyarthi) owes to bring up his daughter to a good position. Madhu becomes Siluvai’s favorite. Esther enters the scene with lots of change in her character. Siluvai comes to know about their love affair, and his decision forms the rest of the story. In the end, Madhu and Mercy die by falling down from a hill.

The movie begins with the search for an actress Anjali (Sonia Agarwal) by a scribe (‘Punnagai Poo’ Geetha). Once a sought-after heroine, Anjali vanishes one fine day and efforts to trace her ends in vain. The journalist manages to locate her after several hardships. Cut to flashback, the travails of Anjali is revealed. Anjali is the daughter of a poor folk artiste Devarajulu (‘Yogi’ Devaraj) in Andhra Pradesh. One day, her mother resolves to make her an actress and comes to Kodambakkam. The mother and daughter climb every stairs and go around every studio in Kodambakkam and Vadapalani. They meet with failures everywhere until they are forced to agree for casting couch. One compromise on the part of Anjali bags her heroine’s role. She fortunately makes it big. The nature of her mother changes… She becomes greedy and runs madly behind money. Anjali is exploited by few in the industry. Unable to tolerate all humiliation, Anjali decides to take extreme decision in her life.

Velan hates his stepfather and his half-brother Balan.As a police officer,he makes an enemy out of a local politician,who uses the hostility between the stepbrothers to fulfil his own nefarious plans.

Ganesan (Jithan Ramesh) is a happy-go-lucky youth in a village. A great admirer of actor-director T. Rajendar, he spends time with his friends, such as Soori and a few others. This is ridiculed by his father (Jayaprakash). Ganesh’s life takes a turn when he comes across Sandhya (Sanchita Padukone). She is a friend of his sister, who comes on a vacation to the village. He admires her beauty and falls for her. When Ganesh gathers guts to open his heart to Sandhya, enters Valli (Suhasini), Ganesh’s uncle’s (Ilavarasu) daughter. Fearing her father will get her married to a local goon Durai (Bose Venkat), she decides to marry Ganesh. Suddenly, Sandhya falls ill, and Ganesh takes her to the hospital. He is shocked when the doctor (Prakash Raj) informs that she has pancreatic cancer and will die in a few months. Ganesh, in a bid to keep her happy until her death, marries her and comes home. He incurs his father’s wrath and is driven out of the house. However, a sudden twist in the plot causes the movie to end on an emotional note.

Jithan 2 is second installment in the Jithan franchise. The film tells the tale of a man who encounters paranormal activities in his new home. Does the ghost have a mission? Will it ever exit the house? That forms the crux of the story.